Share of Cost, Gene Mutation May Have Effect on Benefit of Aspirin Use For Colorectal Cancer
Tuesday, Feb. 11th 2014 1:00 PM
In 2 large studies, the association between aspirin use and risk of colorectal cancer was affected by mutation of the gene BRAF, with regular aspirin use associated with a lower risk of BRAFwildtype colorectal cancer but not with risk of BRAFmutated cancer, findings that suggest that BRAFmutant colon tumor cells may be less sensitive to the effect of aspirin, according to a study in the June 26 issue of JAMA. Colorectal cancer is a leading cause of cancerrelated death worldwide.
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